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1. Introduction. The phosphatidylinositol-3-kinase (PI3K)/Akt (PI3K/AKT) pathway is the most commonly altered signaling pathway in human cancers [].Alterations in the PI3K/AKT/mTOR pathway were identified in 38% of cancer patients including mainly phosphatase and tensin homolog (PTEN) (30%), followed by mutations in PIK3CA (13%) .

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